Correction: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling
نویسندگان
چکیده
After our work was published, we found that some of the terms in the equations were incorrect and that there were some typographical errors in the abbreviations. In the section 'Single adjusting compartment' in Materials and Methods, VS should be VSAC. In the last paragraph of Results, QSAC should be QSAC. The correct equations are included in this article. These corrections will not affect the results of this study. Correction After our work was published [1], we found that some of the terms in the equations were incorrect and that there were some typographical errors in the abbreviations. In the section 'Single adjusting compartment' in Materials and Methods, VS should be VSAC. In the last paragraph of Results, QSAC should be QSAC. The correct equations are as follows: These corrections will not affect the results of this study. Competing interestsThe authors declare that they have no competing interests. References1. Ando H, Izawa S, Hori W, Nakagawa I: Utility of a single adjustingcompartment: a novel methodology for whole body physio-logically-based pharmacokinetic modeling. Theoretical Biologyand Medical Modelling 2008, 5:19.Published: 8 December 2009Theoretical Biology and Medical Modelling 2009, 6:29 doi:10.1186/1742-4682-6-29Received: 26 November 2009Accepted: 8 December 2009 This article is available from: http://www.tbiomed.com/content/6/1/29© 2009 Ando et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. dCrdtQrVrC CrKprCLr CaVra=−⎛⎝⎜⎞⎠⎟ − ⋅(2) dCgidtQgiVgiCCgiKpgiCLgi CaVgia=−⎛⎝⎜⎞⎠⎟ −⋅(3)dClungdtQtotVlungCClungKplungv=−⎛⎝⎜⎞⎠⎟(4) dCidtQiViC CiKpia=−⎛⎝⎜⎞⎠⎟(5)
منابع مشابه
Physiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours
Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...
متن کاملA computer-aided framework for development, identification and management of physiologically-based pharmacokinetic models
The objective of this work is the development of a generic computer-aided modelling framework to support the development of physiologically-based pharmacokinetic models thereby increasing the efficiency and quality of the modelling process. In particular, the framework systematizes the modelling process by identifying the workflow involved and providing the required methods and tools for model ...
متن کاملSoftware Supported Modelling in Pharmacokinetics
A powerful new software concept to physiologically based pharmacokinetic (PBPK) modelling of drug disposition is presented. It links the inherent modular understanding in pharmacology with orthogonal design principles from software engineering. This concept allows for flexible and user-friendly design of pharmacokinetic whole body models, data analysis, hypotheses testing or extrapolation. The ...
متن کاملPhysiological spaces and multicompartmental pharmacokinetic models
The idea of body compartments has its origins in physiology and antedates their use in both physiologically-based predictive pharmacokinetic models and in the simpler compartmental models used to analyze pharmacokinetic data. Whereas physiologically-based pharmacokinetics has evolved to use increasingly sophisticated organ-based models, most compartmental models for data analysis are used witho...
متن کاملPhysiologically-based pharmacokinetic modelling for the reduction of animal use in the discovery of novel pharmaceuticals.
The challenges of physiologically-based pharmacokinetic (PBPK) modelling and approaches to replacing the use of animals, in order to determine drug pharmacokinetics, are discussed. Reference is made to the limitations of in vivo animal studies in drug discovery. In particular, the ways in which animal studies contribute to drug attrition during the post-preclinical phase of testing are considered.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2009